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Crispr-Cas9 Genome Editing Induces Megabase-Scale Chromosomal ...

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Crispr-Cas9 Genome Editing Induces Megabase-Scale Chromosomal ...

CRISPR-Cas9 has been rapidly adopted to generate cell line models of disease. Here the authors show, while attempting to establish a congenital erythropoietic porphyria model, unexpected chromosome truncations generated by a p53-dependent mechanism.

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