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Targeting IFNα to Tumor by Anti-Pd-L1 Creates Feedforward Antitumor ...

SOURCE ARTICLE:
Targeting IFNα to Tumor by Anti-Pd-L1 Creates Feedforward Antitumor ...

Despite the presence of tumor-infiltrating lymphocytes, many patients do not respond to PD-L1/PD-1 blockade therapy. Here they show that PD-L1 antibody armed with interferon-α (IFNα) improves tumor targeting and antigen presentation while countering innate or T-cell-drive PD-L1 upregulation, and overcomes resistance to checkpoint blockade therapy.

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